If you’re on the lookout for a comforting yet surprisingly light dish that bursts with flavor, you absolutely need to try this Rotel Chicken Spaghetti Squash Casserole. It captures the cozy charm of a classic casserole but swaps out heavy pasta for tender, naturally low-carb spaghetti squash strands. Packed with juicy chicken, zesty Rotel tomatoes, and a dreamy blend of dairy-free cream cheese and coconut milk, this casserole combines creaminess and a touch of spice in every delightful bite. It’s a perfect weeknight supper or a crowd-pleaser for your next gathering that’s as nourishing as it is delicious.

Rotel Chicken Spaghetti Squash Casserole Recipe - Recipe Image

Ingredients You’ll Need

All of these ingredients are straightforward but come together to make a casserole that is vibrant in taste and texture. Each component plays a crucial role—from the tender chicken bringing protein and heartiness, to the creamy base that melts everything into a luscious, savory mix.

Spaghetti squash (1 medium, about 2 pounds): The star ingredient offering a veggie twist with its stringy, pasta-like texture.
Olive oil (1 tbsp): Adds a fruity richness that helps roast the squash to perfection.
Chicken breast (3 cooked and diced): Provides tender protein and a mild flavor that soaks up all the spices.
Rotel (1 1/2 cans, drained): Infuses the dish with a tangy and slightly spicy tomato and chili kick.
Salt (1 tsp): Essential for balancing and highlighting all the other flavors.
Garlic powder (1 tsp): Offers a sweet, aromatic depth that warms the palate.
Onion powder (1/2 tsp): Lends a gentle sharpness without overpowering the dish.
Black pepper (1/2 tsp): Brings a mild heat that complements the Rotel’s spice.
Kite Hill cream cheese (1 container): Adds a creamy, dairy-free smoothness that binds everything wonderfully.
Ghee (1 tbsp): Gives a nutty richness and helps meld the sauce together on the stove.
Coconut milk (1/2 cup, canned unsweetened): Creams the sauce while keeping it dairy-free and subtly sweet.
Nutritional yeast (3 tbsp): Sprinkles a cheesy, umami flavor that rounds out the taste.

How to Make Rotel Chicken Spaghetti Squash Casserole

Step 1: Prepare the Spaghetti Squash

Begin by preheating your oven to 400°F and lightly spraying a casserole dish with cooking spray. Cut the spaghetti squash in half lengthwise and scoop out all the seeds and fibrous ribs—the blank canvas for all your flavors to shine. Drizzle the inside with olive oil, and sprinkle with salt and pepper so it roasts with a nice seasoning base. Place it cut side down on a baking sheet, and poke a few holes in the skin with a fork to let steam escape. Roast for 30 to 40 minutes, until the squash is tender and the exterior just starts to brown. Once out of the oven, flip the squash so the cut side is up and, when cool enough to handle, scrape out the strands with a fork into a large bowl. The strands will mimic spaghetti perfectly and soak up all the sauce later.

Step 2: Cook the Chicken and Make the Sauce

Now reduce the oven heat to 350°F. Dice your cooked chicken breasts into bite-sized pieces and add them to a skillet over medium heat. Drain your cans of Rotel thoroughly to avoid excess liquid, then pour it into the skillet. Stir in the Kite Hill cream cheese, nutritional yeast, coconut milk, ghee, salt, garlic powder, onion powder, and black pepper. Heat this mixture gently for about 5 minutes, allowing the cream cheese to melt and the flavors to meld into a rich, creamy sauce that coats the chicken beautifully.

Step 3: Combine and Bake

Transfer the chicken and sauce mixture to the bowl with the spaghetti squash strands and mix everything together until well combined. Pour this cheesy, spicy concoction into your prepared casserole dish. Pop it into the oven and bake at 350°F for 30 to 40 minutes until it’s bubbling, golden around the edges, and heated through. This step melds all those wonderful layers into one cohesive and utterly delicious casserole ready to comfort and satisfy.

How to Serve Rotel Chicken Spaghetti Squash Casserole

Garnishes

To elevate your Rotel Chicken Spaghetti Squash Casserole even further, sprinkle freshly chopped cilantro or parsley for a bright herbal lift. A dollop of dairy-free sour cream or a squeeze of lime can add a zesty contrast that brightens every bite. If you love a bit of heat, a few thin slices of fresh jalapeño or a dash of smoked paprika can be fantastic additions on top.

Side Dishes

This casserole is quite filling on its own but pairs wonderfully with simple sides like a crisp green salad tossed in a light vinaigrette or roasted seasonal vegetables to add extra color and nutrients. For something heartier, garlic bread or warm dinner rolls complement the creamy casserole texture beautifully, soaking up every bit of the sauce.

Creative Ways to Present

Looking to impress at a dinner party or bring a fun twist? Serve the casserole in individual ramekins for a personal touch, or spoon portions into hollowed-out roasted bell peppers for a colorful presentation. You can even turn the leftovers into stuffed lettuce wraps or top your morning eggs with reheated casserole for an adventurous breakfast.

Make Ahead and Storage

Storing Leftovers

Leftover Rotel Chicken Spaghetti Squash Casserole keeps beautifully in an airtight container in the fridge for up to four days. The flavors actually deepen overnight, making it a perfect next-day lunch or dinner that’s quick to reheat.

Freezing

This casserole freezes very well if you want to prepare meals in advance. Let it cool completely, then transfer it to a freezer-safe dish or individual portions in containers. It will keep for up to three months. Thaw overnight in the fridge before reheating for best results.

Reheating

Reheat your casserole covered in the oven at 350°F for about 20 minutes, or until warmed through. For a quicker option, you can microwave individual servings on medium power, stirring halfway to ensure even heating. Adding a splash of coconut milk before reheating helps keep the texture creamy and fresh.

FAQs

Can I use other types of squash instead of spaghetti squash?

While spaghetti squash is ideal for that stringy, pasta-like texture, you can try other varieties like delicata or butternut squash, though the texture and moisture content will differ. The casserole may be creamier or softer depending on the squash you choose.

Is this recipe dairy-free?

Yes! This Rotel Chicken Spaghetti Squash Casserole uses dairy-free cream cheese and coconut milk to keep it creamy and delicious without dairy, making it friendly for those with lactose intolerance or dairy allergies.

Can I use canned chicken or rotisserie chicken?

Absolutely. Pre-cooked chicken of any kind works well in this recipe. Rotisserie chicken adds extra flavor and convenience, while canned chicken is a quick substitute but may require rinsing for a fresher taste.

How spicy is this casserole? Can I adjust the heat?

The Rotel tomatoes give a gentle kick, but it’s not overwhelmingly spicy. If you prefer milder flavors, choose mild Rotel or drain the tomatoes well. For extra heat, add diced jalapeños, hot sauce, or cayenne pepper to taste.

Can I make this recipe vegetarian or vegan?

You sure can! Simply omit the chicken and add hearty veggies like mushrooms, zucchini, or tofu for protein. Make sure your cream cheese and other ingredients are vegan-friendly, and you’ll have a delicious plant-based casserole.

Final Thoughts

This Rotel Chicken Spaghetti Squash Casserole is truly one of those dishes that feels like a warm hug in food form. It’s easy to make, packed with flavor, and perfect for any occasion. Whether you’re feeding family or meal prepping for the week, give this recipe a try—you won’t regret inviting this cozy casserole to your table again and again.